بررسی تأثیر عصاره آبی الکلی گیاه آویشن شیرازی( Zataria multiflora BIOSS) …

مقدار فاکتورهای TC، TG، VLDL ،LDL و HDLخون موش ها، داده ها با نرم افزارSPSS و روش آماری تحلیل واریانس(ANOVA-F test) تحلیل گردیدند.

یافته ها : به نظر می رسد که روغن ذرت و کلسترول هر کدام به طور معنی داری باعث افزایش فاکتورهای چربی خون می شوند. گروه ۴ کاهش این عوامل را نشان می دهد، گروه های ۵و۶و۷ (تیماربا دوزهای مختلف عصاره آویشن) کاهش معنی داری-اگرچه کمتر از گروه ۴- در میزان فاکتورهای چربی، نشان دادند و میزان HDL آن ها افزایش یافته بود.

نتیجه گیری:نتایج حاصل از این تحقیق نشان می دهد عصاره آویشن شیرازی باعث کاهش چربی خون می شود و می تواند به عنوان داروی گیاهی کنترل کلسترول خون مورد استفاده قرار گیرد.

کلمات کلیدی: آویشن شیرازی، فلاونوئید، هیپرکلسترولمی، آتورواستاتین.

Title:

Effect of hydroalcoholic extract of Zataria multiflora Bioss on serum lipids levels in high cholesterol diet fed Rats

By: Zarei Mohammad Ali, Islamic Azad University Arsanjan Branch

zaree_ma@yahoo.com

Abstract:

Background :One of the main factors leading heart diseases is hypercholestrolemia. Research studies have shown that the flavonoid and antioxidant are effective in removing hyperlipidemia.

Materials and Methods: In this study, the effect of Zataria multiflora leaves extract, which contain these compounds has been investigated on hyperlipidemia.

۵۶ Wistar male rats divided in to 7 groups each of which with 8 animals were treated for 4 weeks with 7 dieting systems.The groups are as follows:

Group 1 (Control I): Normal diet and unlimited water and food; Group 2: Daily normal food +3 g/kg corn oil as a vehicle for cholesterol; Group 3 (Control II hypercholestrolemia): Usual daily food+ 2g/kg Cholesterol dissolved in 3g/kg Corn oil; Group4 : Treated like group 3 but with increased 10 mg/kg Atorvastatin as an anti-fat; Groups 5,6,7: Treated like group 3 but recived respectively 100,200&300 mg/kg Z.M. extract. After 4 weeks, and at the end of the experiment, after 14 hours starvation rats got anesthesia with chloroform and blood was Taken from the heart, The blood was collected in test tubes and was transferred to the laboratory. After determining the factors TG، TC، LDL ،VLDL & HDL, Data Was analyzed with SPSS software by ANOFA(Ftest).

Results: Test results showed Increased corn oil alone or With cholesterol, Both increased significantly blood fat factors. As was expected, Group 4 showed reduction of these factors; Groups 5 , 6 & 7 that recived Z.M. extract ,significantly decreased blood fat factors, except HDL that Increased significantly.

Conclusion: Results from this study showed that the extracts of Zataria multiflora has hypolipidemic effects .